Affymetrix CNV / LOH Services

CNVs can consist of deletions, duplications or multi-site variants in DNA segments, ranging from a few kilobases to megabases in length. They are particularly important in genetic research because they can be associated with specific diseases, such as an increased susceptibility to cancer, Parkinson's and Alzheimer's, as well as to conditions like HIV-1 infection and glomerulonephritis.

Certain CNVs also appear to influence drug metabolism and increase sensitivity to particular chemical carcinogens, which will also help to decipher the complex ways in which an individual's genes and the environment impact disease. Moreover, the detection of LOH in the region containing oncosuppressor genes is very important in cancer

DNAVision was the first official Affymetrix service provider  to be trained in the new SNP 6.0 genechip technology. We  can provide you with  SNP genotyping technologies in a high quality environment (ISO 17025).

Analysis of Whole Genome Copy Number Variations

Affymetrix arrays provide a robust  precise platform with high sensitivity for detecting chromosomal alterations throughout a genome using  complex genomic samples.

We provide services using  the genechip array available from Affymetrix:

• Affymetrix 250K/500k Array
• Affymetrix 5.0 Array
• Affymetrix 6.0 Array

Samples

Clients submit frozen or embedded tissues, purified genomic DNA or EDTA-preserved blood.

You can find a description of the protocols following these links :

• DNA isolation from frozen samples
• DNA isolation from FFPE samples

Affymetrix GeneChip Mapping arrays (SNP 250k, SNP 5.0K, SNP 500K, SNP 6.0) are the only tools for high throughput copy number analysis and loss of heterozygosity (LOH) studies in one row.