CNVs can consist of deletions, duplications or multi-site variants in DNA segments, ranging from a few kilobases to megabases in length.
They are particularly important in genetic research because they can be associated with specific diseases, such as an increased susceptibility to cancer,
Parkinson's and Alzheimer's, as well as to conditions like HIV-1 infection and glomerulonephritis.
Certain CNVs also appear to influence drug metabolism
and increase sensitivity to particular chemical carcinogens, which will also help to decipher the complex ways in which an individual's genes and the
environment impact disease.
Moreover, the detection of LOH in the region cotaining oncosuppressor genes is very important in cancer disease.
DNAVision was the first official affymetrix service provider provides to be trained for the new SNP 6.0 genechip and can provide you with the SNP genotyping technologies in a high quality environnement (ISO 17025)
Affymetrix arrays provide a robust and precise platform for detecting chromosomal alterations throughout a genome with high sensitivity using full complexity genomic samples
We provide services on the available genechip array from Affymetrix:
Clients submit frozen or embedded tissues, purified genomic DNA or EDTA-preserved blood.
You can find a description of the protocols following these links :
Affymetrix GeneChip Mapping arrays (SNP 250k, SNP 5.0K, SNP 500K, SNP 6.0) are the only tool for high throughput copy number analysis and Loss of Heterozygosity (LOH) studies in one row.
